DontDie: Age Bursts, Body Clocks, and Gut-Centric Metformin

• Aging Occurs in Distinct Bursts at 44 and 60: A study from Stanford University found that aging doesn't just happen gradually but occurs in specific bursts around ages 44 and 60. Researchers observed significant changes in metabolism, kidney function, and immunity at these key transition points.

• Why it matters: Understanding these critical periods of biological change could lead to new diagnostic tests and preventative strategies for age-related diseases. It highlights the importance of lifestyle interventions in midlife to promote healthy aging.

• Human Longevity Lab Launches to Study Aging Reversal: Northwestern University's Potocsnak Longevity Institute has launched the Human Longevity Laboratory, a longitudinal study investigating the relationship between chronological and biological age across different organ systems. The lab aims to validate interventions that may slow or reverse aging processes.

• Why it matters: This comprehensive research could lead to methods for slowing aging and delaying the onset of age-related diseases, potentially extending healthspan. The study is particularly focused on populations at risk for accelerated aging, such as those with HIV or chronic kidney disease.

Chronobiology Boost: Sync Your Meals with Your Body Clock

Think it's just what you eat that matters? Think again. When you eat could be just as crucial for your health. Welcome to the world of chrononutrition, where timing is everything.

How to do it:

1. Eat your largest meal before 3 PM.

2. Aim for a 12-hour overnight fast (e.g., 7 PM to 7 AM).

3. Avoid late-night snacking, especially carbs.

4. Have your coffee after breakfast, not before.

Why it works: Your body's metabolic processes follow a circadian rhythm. Insulin sensitivity and metabolism are highest earlier in the day. Aligning your eating patterns with these rhythms optimizes nutrient absorption and energy utilization.

Pro tip: Use a meal-tracking app to log not just what you eat, but when. Look for patterns in energy levels and sleep quality related to meal timing.

"Metformin only works by affecting AMP kinase and mTOR"

 This oversimplifies metformin's complex mechanisms of action and ignores recent research findings.

The truth: While metformin does influence AMP kinase and mTOR pathways, recent studies suggest its primary mechanism might be altering gut bacteria. CT PET scans show increased glucose activity in the bowel loops of metformin users, supporting this theory. Metformin's effects may be more diverse and gut-centric than previously thought.

What to do instead: 

• If prescribed metformin, focus on gut health through diet and probiotics.

• Discuss with your doctor how metformin might interact with your gut microbiome.

• Stay updated on the TAME (Targeting Aging with Metformin) trial results for more insights.

• Consider comprehensive gut health testing if you're on or considering metformin.

Is rapamycin really the miracle drug for longevity, and how can I use it safely?

Rapamycin has been hailed as a potential "miracle drug" for longevity, but the reality is more nuanced. Originally developed as an immunosuppressant, rapamycin inhibits mTOR (mechanistic target of rapamycin), a pathway involved in cellular growth and metabolism.

Studies in mice have shown impressive life extension effects—up to 60% in some cases. In humans, rapamycin has demonstrated benefits like enhanced immune function in older adults and improved cardiovascular markers. However, it's not without risks, including potential immunosuppression and metabolic effects.

Currently, rapamycin isn't approved for anti-aging use, and long-term effects in healthy individuals aren't fully understood. Some longevity physicians are prescribing it off-label, typically in intermittent, low doses to minimize side effects while potentially capturing benefits.

If you're considering rapamycin, it's crucial to work with a knowledgeable physician who can monitor your health closely. They might start with bloodwork to assess your baseline health and potential contraindications. Remember, rapamycin is potent medicine—not a supplement—and should be treated as such.

While promising, rapamycin isn't a silver bullet. It's most effective when combined with a healthy lifestyle, including proper nutrition, exercise, and stress management.